Very Edge-y comment.

Different person, unrelated to the above advertisement but:

Sometimes any diet.

Mental health struggles can exacerbate, (and be exacerbated by!) forgetting to eat, not wanting to eat,

forgetting or passing up the things that keep you in homeostasis, choosing the less correct things because of an emotional response, a physiological response in a “diminished” state.

Non-diagnostician

Point stands.

So does the lack of a model for Alzheimer’s,

and other chronic illnesses,

that the consumer-facing medical industry prefers to dismiss.

The tau hypothesis is looking like a good model.

I didn't argue a model beyond one cause.

“Complications due to unaddressed microbial infection” will read as pretty confident, too,

but it’s still pretty vague once you’ve really dug in.

That's why I was emphasizing "one way" and "can begin".

Clearly viral infection may be a distal factor but it is not the proximate cause of Alzheimer's... which is quite conclusively due to protein aggregates.

I don’t find any of it conclusive.

Protein aggregates seem like the effect, with many causes.

Yes, exactly. Whether it APOE mutation, traumatic injury, metabolic dysfunction, Herpes infection, or some other inflammation that upregulates kinases, you end up with hyperphosphorylated tau which in turn forms the neurofibrillary tangles that destroy nutrient transport in neurons and eventually kills them.

"Neuron death by protein aggregates" is the best way to define Alzheimer's. Anything more specific refers to only one of those aforementioned causes; anything less is just "brain don't work no more."

These clickbait headlines are so frustrating, especially since the article itself explains the tau mechanism and all the progress that has been made in understanding the disease.

How many of them have their lymphatic and glymphatic systems effectively halted by parking their bodies in a chair or being bedridden?

Even the most unwell person (in the US) is still dragging themselves to the store and work, on average.

Simple, brief movement that we often relieve the elderly of is the pump that actions the lymphatic system.

Being older brings its own additions to the table.

> your brain just gives out.

Meaning, failing of the glymphatic (and possibly lymphatic!) systems.

Are those things not linked to cPTSD,

which is linked to nervous and endocrine dysfunction,

which is linked to Alzheimer’s/Dementia?

It’s a shame how many of those people are practitioners!