Someone has a chart somewhere that shows responses in that subreddit getting more and more anti-conciliatory over time. I think it’s online misanthropy (measured by Reddit responses) increasing over time rather than it being objectively never the correct choice.

Also the rules and norms of the subreddit has changed over time, which has led to spin-off subreddits that serve those purposes.

Kind of makes sense that stopping taking a drug that reduces heart attack and stroke risk leads to a return to the higher risk of before.

We see risk reduction for heart attack and stroke for people on GLP-1s even without weight loss, which belies the idea that the protection only comes from losing weight.

Edit: In fact, from the study -

BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),

Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted

NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted

BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)

Have you got a link to the study those figures are actually from? I'm not saying their wrong but I would like to read and understand them for myself before I change my mind.

> BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted),

So, what, was 35.86 the BMI at the start, 34.57 the BMI when they stopped taking the drug, and 35.48 after some interval?

For someone of a fairly average height, say 1.86 metres (that's a little under how tall I am) a BMI of 35.86 would be 124kg which is ridiculously fat and 34.57 would be around 119.6kg so you're looking at a loss of around 4.5kg or so.

That's a good shit and a haircut, in the grand scheme of things. It's fairly normal for someone's weight to fluctuate by a kilo up or down (a range of 2kg over normal) and not utterly off the map for a range of four kilos on a day-to-day basis, especially in obese people. That's why you're not supposed to keep weighing yourself and obsessing over the weight.

What is it about GLP1s that bring out the kooks who suddenly think diet and exercise are the only valid medical treatment? Is it a moral issue?

Unless we're talking about emergency care, most pharmaceuticals are completely unnecessary and carry serious risks.

There's not a single qualified doctor out there that would promote drugs before preventative measures.

Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue.

Saying they should try this first at this point in the game is like having your support case escalated 5 times already and them saying "have you tried turning it off and on again"

> Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue.

If it's not working for you, it may be because you haven't sorted the "diet" bit.

Are you eating "low fat" or "low calorie" things? Because those are not food and they will make you fat.

Eat food, just a bit less of it than you do now.

Obviously the calories in are greater than the calories out if the diet doesn't work.

That's not the point.

The point is the vast majority of overweight and obese people try to diet and do not succeed in it.

As best as I can tell, people are very attached to having achieved their body weight through whatever means they have determined are valid and derive self value from it, and believe that GLP-1s are cheating to achieve a result they worked harder for.

Yes, it's a moral issue.

What you need to understand is there are a lot of people where all they have is being skinny and appearing to be healthy. Without that, there's nothing left for them.

For a long time, there has been a moat that they can use as a justification for why they're better. They can say "well I work hard, I eat right, I put in effort!" The idea that others can achieve that without any of that means... well, they did it all for nothing. In their heads.

The dirty little secret? Many of them don't do any of that, it's just a delusion. Always has been. I'm skinny, you think I go to the gym? Fuck no! I should, but I don't. And I eat whatever I want.

But if a lot of people have to face the reality that their most redeeming quality is nothing of their doing, that would ruin them. Ruin them. They could just, like, get achievements or something but that's hard. Continuing the delusion is easy.

Your comment is all kinds of wrong.

A) it does have cardio protective effects.

It does reduce your appetite, and for most people have very few side effects. If you get nausea you're titrating up too fast. Most people, because it slows gastric emptying, it doesn't make them shit themselves "inside and out". GLP1s are a decent option for treating ibs-d or bile acid issues and is better tolerated than your bile acid sequesterants.

> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

This victim blaming advice has been given for decades and obesity rates have been climbing for decades. Only glp-1s have reduced that.

> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

Oh wow it's so simple! why has nobody thought of this before??

You've been being told this your whole life.

You still think mass-marketed "low fat" foods are good for you.

You still think you can pop a pill to make your problems go away.

I dunno, browsing McMaster-Carr feels like both shopping and creating at the same time.

Typing is just choosing from the latent space something special, too. Could just be random words, or, even fewer, random grammatically correct sentences.

In my experience, it does actually work. Tesla model s had an issue with the flash memory endurance, and the NHTSA made them replace it. Which they did, and upgraded the 3G modem to LTE while they were at it. My 2013 Model S is still going strong, still gets software updates.

> the NHTSA made them replace it

They forced them to replace it because it was recognized as a manufacturing/design defect. This is a very different scenario from "normal wear" replacement.

Additionally the Tesla model S is still in production with only a facelift. Therefore the parts that are produced are not unavailable (or not supplied).

I think you can't replace/upgrade the flash and modem yourself without the assistance of a Tesla dealer.

Even copper has vastly lower resistance when cryogenically cooled. It's not a bad idea for some applications, and water cooling is already a good way to increase power density.

I learned recently that the inductive heating coils used for metallurgy (smithing) are copper tubing with coolant flushing through them. The copper tries to heat up along with the bar you’re heating in the coil. Both from resistance and from radiative heating.

I feel like people in these comments and commentators in general are just kind of ignoring the fact that the US produces more helium than Qatar, and in fact more helium than the entire Middle East combined, nearly 50% of the global total. The sale of the "helium reserve" is (mostly) irrelevant as well, because there's massive domestic helium production. https://www.wmi.badw.de/the-institute/helium-liquefaction-pl...

I get that the current situation is stupid, but can we at least be accurate? Qatar is FAR from the only source of helium. (And yes, helium of any type can be purified to high levels. That's also not just a Qatar thing.)

This isn’t accurate. FreeCAD merged the main changes from that fork (RealThunder) to fix (well, mitigate) the problem. That’s the big thing with 1.0.

Although… as others have noted, this is a problem with basically all CAD packages, as on a fundamental level, it depends on user design intent. Just some have enough bandaids that it’s more rare.

My statement was accurate as of _when_ I moved away from FreeCad. I'm happy they merged the RealThunder work. But they dilly-dallied for a long time while people were demanding a fix and one was available. Doesn't speak well of their org politics.

The org politics (which has actually improved tremendously in the last 3 years), in particular related to realthunder's solution, was related to code compartmentalization and maintainability. Yes realthunder's solution worked, and he submitted massive monolithic PR's to FreeCAD main for integration and then basically disappeared. Ultimately, it ended up getting chunked out into smaller parts and reverse engineered and restructured by a couple of other FreeCAD dev's under grants paid for by FreeCAD and it took them about a year to accomplish. The man who did the bulk of the work, Brad McLean, unfortunately died shortly before 1.0 released with all of his work included in it.

Not trivial work.

Lithium is not a rare earth mineral. Huge pet peeve. This is a technical term. It’s also not particularly rare.

Rate earth minerals aren't necessarily rare, it means that you have to move a huge amount of earth to get a tiny bit of ore. That's still true for lithium and its mining pretty polluting too. And it's limited to specific regions globally.

Our sea is full of sodium however.

No, “rare earth minerals” are referring to an exact section of the periodic table, referring to exactly 17 elements, like “lanthanide series” or “noble gases”. It is a technical term, not a descriptive one. Lithium is not in the list.

You’re also wrong about lithium’s availability, but that’s another story.

“Rare” as in “rarified”, not “uncommon”.

So if OpenAI stayed a non-profit, they'd be okay?

yes?

I mean… what is the assumed replacement, then? Residual moral sensibilities from our obsolete judeochristian heritage?

Just as a random proposal, not even lightly thought out. In priority order with realistic exceptions:

- do your best to be not dead, safe, and healthy for the next few years

- do your best to make those around you not dead, safe, and healthy for the next few years

- do your best to treat others around you how you would wish to be treated

- do your best to treat others around you how THEY would wish to be treated.

Yes. There is a quote from james allen that I like. "There is no greatness without goodness"

So, the Golden Rule?

With the caveat of safety and well-being it is on the list. But note that it isn't the highest one.