Honestly as wide spread as it is, managing group policy sanely is still a challenge I've found - it's very resistant to configuration as code.
Linux has a lot of the pieces but is principally lacking a solid distribution system - in particular a big missing component is the network-based SELinux policy distribution system which you can see some hooks in for the concept of a "policy server" which never eventuated.
SELinux would be a lot more viable if it had a solid way to federate and distribute policy and has some nice features in that regard (i.e. the notion that networked systems can exchange policy tags to preserve tagging across network connections).
> managing group policy sanely is still a challenge I've found - it's very resistant to configuration as code
Imho, this was historically (and continues to be) Microsoft's Achilles heel.
Large parts of the company reflexively wrote features / tooling as manual-first, code-second (or never).
In hindsight, what was missing was a Gates-level memo circa 2000 similar to Amazon's API one: all teams are required to build their configurators to be programmatically exposed.
Unfortunately, I don't think Ballmer was enough of a technologist (and was likely too distracted) to intuit that path not taken.
I've been trying to use Exchange support at work but there's an ongoing problem that the OAuth login screen can't display PIN prompts for things like Yubikeys.
So I'd love to use the feature, but modern corporate auth defeats it currently.
This is basically "just don't use things you don't enjoy" and the trouble of our time seems to be the number of people who can't or won't do that.
It's somewhat an age thing but also definitely a lot of people in all generations never learn it: you can just stop using things. Walk away and suddenly find you never want to look back, and if you do it's entirely unappealing.
Frankly, who are these people? Because this is just another "they" idle conspiracy theory.
"They" are against me.
Ironically I could cite a very specific group this applies to: fitness influencers in the wake of ozempic. "Natural weight loss" and FUD about the drug took off when it hit mainstream awareness because it really was a direct threat to them. Of course this group also tends to heavily abuse other drugs as they age out - because being a trim fitness inflencer is easy in your 20s, keeping it going into your mid-30s is a lot more difficult.
I was thinking specifically of political pundits who are doing a roaring trade (in opinion columns, TV hits, book promotions etc) talking about authoritarianism and its many causal factors. They're curiously mute when it comes to discussing solutions, with very generic advice like 'go to a protest' or 'vote for the opposition' despite the abundant evidence from authoritarian regimes around the world of these tactics not being very effective. You never hear them talk about things like general strikes or mass civil disobedience campaigns for some reason.
Pipelines can be protected. Just putting it in the ground for example. Or you build a "bomb" proof shelter over it - Iran's missiles are not bunker busters, we know how powerful they are and can design for that. Air defense systems are getting better too.
We have no specific reason to believe there are concerns with GLP-1s for cancer or anything else, beyond the mildest signal in rodent studies around thyroids.
We do not have robust clinical data for things like BPC-157 but we do have strong preclinical data and an understanding of the mechanisms in play.
I use BPC-157/TB-500/Ghk-CU/KPV - so I'm certainly OK taking the risks. But those mechanisms mentioned before? The same things we're counting on for healing and inflammation reduction are the same things that we know can cause an increase in tumor growth rate and chance of metastasizing. VEGF/VEGFR2 expression are even suppression targets for some cancer therapies.
Are there powerful and useful medications out there, available today, that we both don't have good scientific data on and are free enough of serious side effects? For sure! Is everything out there that, though? No. Some things that work will have too serious of a side effect profile to be feasible. Some things won't work at all, despite however much anecdata is out there.
As for the general idea... I agree there's no law that says a medicine with a strong positive effect must also have strong side effects. And we have plenty that don't - statins, particularly the latest generation, like pitavastatin, are effectively side effect free for the hugely overwhelming majority of people and have great lipid lowering effects. Even older ones showed extremely minimal incidents of things like muscle pain - a vanishingly small number of people relative to the total amount on the medications report muscle pain, and when investigated, quite a lot of even that ends up being unrelated to the statins. Yet the narrative persists that make it sound like anyone on statins is going to have their muscles ache 24/7
I'm glad we have GLP-1, and I don't think there are really major side effects. But they are ineffective outside clinical trial setting for treating obesity.
It seems to be like treating alcoholism with disulfiram: it's a miracle in clinical trials but in the real world the patients just lower the doses or discontinue treatment after 1-2 years and go back to their old habits.
I hope it sounds less wild if you think obesity as disease of addiction. Reducing GLP1 dose can increase the enjoyment in eating, so it makes sense why treating obesity with GLP1 is like treating alcoholism with disulfiram: Effective in theory but hard to adhere outside trials.
Type 1 diabetes (or majority of diseases) doesn't involve addiction.
It is not ineffective outside of clinical trials. All the evidence says that people gain some weight back after they discontinue treatment - which is not a lack of efficacy. But they also usually gain back less then they lost.
I can't reply elsewhere so I will reply to this again.
> In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this?
Anecdotes like this are interesting but in medicine they are not sufficient to make factual statements about drugs. In meta-analyses there is weight regain which is steeper as more weight is lost during treatment [1].
The weight regain seems to be rather slow, it can take years until the baseline weight is reached.
> In meta-analyses there is weight regain which is steeper as more weight is lost during treatment
What does "steeper" mean? The studies I've seen show a net weight loss, even after regain, for the median patient.
> The weight regain seems to be rather slow, it can take years until the baseline weight is reached
Maybe. Right now, however, the evidence shows solid effects outside clinical settings. Your original statement was wrong–your sources own refute the claim.
If you're arguing the effects in the real world haven't consistently been as ridiculous as they were in clinical trials, sure, you get a brownie point. But broadly speaking, these drugs are terrifically effective, both when taken for life and when taken intermittently.
If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.
I emphasize it's like the drug disulfiram: Very effective as long as patients take the full dose, but the lack of real-world efficacy stems from the difficulty in adhering to the treatment.
> the lack of real-world efficacy stems from the difficulty in adhering to the treatment
Do you have a source for this "lack of real-world efficacy"?
> This study found that 84.4% non-diabetic patients stop taking GLP-1 drugs within two years
"With a with a median on-treatment weight change of −2.9%" [1]. Of those who discontinued and experienced "weight gain since discontinuation," they were "associated with an increased likelihood of GLP-1 RA reinitiation."
I'm genuinely struggling to see how this source shows real world inefficacy. In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to.
Out of curiosity, what sources lead you to believe this?
Also LOL at the notion "peptides are safe because GLP-1 exists".
Pretty much all venoms are mixes of short (10-15 base) peptide chains.
It's the naturalistic fallacy in an utterly perverse form ( and also goes to show why a regulatory system is good: the average person has no idea that they're dealing with or even common sense about it).
FDA is a money sink. People basically bribe to get their own self tests approved much like the airlines have their own FAA inspectors that approve their own self tests under duress and bribes. It's all a scam and everyone here knows this even if they won't admit it.
Nullify the FDA, FAA and at least half of the other orgs. Give at least half of those budgets to the people. Make aircraft smart enough to evade all obstacles. Make it technically damn near impossible to collide with anything. Make aircraft coordinate themselves. All doable. Force retire all FDA and FAA and give them a balloon, a golden wrist-watch and send them away.
Give people an app to paste in all the things they take or plan to take in terms of foods, supplements, drugs, their allergies. Let the best AI figure out what will happen.
Medicine doesn't ignore nutrition, you just don't like the answers.
And it shows on the research: e.g. does creatine help muscle building? No.[1] But cue some anecdote from someone where they also changed a dozen other things at the same time but are sure it was that.
Creatine is probably the most well-studied nutritional supplement we have, and one of the most efficacious. You are presenting a single study to counter that. Not even a meta-analysis, but a single study of just 54 participants who did not exercise at all previously (from the study; "Apparently healthy individuals, with a body mass index of ≤30 kg/m2 and not meeting current physical activity guidelines of at least 150 min of moderate-intensity exercise were included. Individuals who undertook [resistance training] within the previous 12 months were excluded"). The general consensus is that it is absolutely helpful in muscle-building. See, for example [0] and [1]. Beware the man of one study. https://slatestarcodex.com/2014/12/12/beware-the-man-of-one-...
[1]: https://www.mdpi.com/2072-6643/17/17/2748 - "A total of 69 studies with 1937 participants were included for analysis. Creatine plus resistance training produced small but statistically significant improvements... when compared to the placebo."
Linux has a lot of the pieces but is principally lacking a solid distribution system - in particular a big missing component is the network-based SELinux policy distribution system which you can see some hooks in for the concept of a "policy server" which never eventuated.
SELinux would be a lot more viable if it had a solid way to federate and distribute policy and has some nice features in that regard (i.e. the notion that networked systems can exchange policy tags to preserve tagging across network connections).
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