As a short adult male (5'5" - 165cm), it's always been difficult to find pants or jeans with a 28" inseam. Surprisingly, AmazonBasics line of clothes is one of the few mass produced consumer brands that has this size. Niche alternatives like Peter Manning are expensive, so it's great Amazon does this.
In theory, the claim in pants from retailers over time was that you could "just get them hemmed" — but if your jeans shape is bootcut or flare, then the leg curves sewn into the fabric will be in the wrong places for your knees, and/or you'll end up hemming off the flare. This gets especially frustrating in women's fashion because bell bottoms are popular, and there's no way to hem them without losing the 'bell' at the 'bottom' of the leg — but retailers only produce them in specific waist-inseam pairings, and so if you want to wear nice jeans with a nice flare, you have to get very lucky in finding them (especially if you're low-rise!) if they happen to exist at all.
I'm like 1 cm taller than you and the pain is real.
And pants are still kind of doable, but mountain bikes? My enduro rig is size XS on 27.5 rims and with manufacturers dropping 27.5ers I expect this to be the last bike that feels anywhere close to "nimble". Also RIP women riders, but that's been the case for years now.
I also have proportionally small feet (size 39 EU but wide as fuck, so I only wear expensive minimalist shoes with wide toe boxes) and small hands (RIP piano, I'm not hitting an octave ever).
and theres nothing subjective about a broken leg, no two doctors would disagree on a broken leg like they would disagree over mental health conditions. you meant to say physical "health" is subjective, ie what we class as "unhealthy".
> Symptoms and/or behaviors that have persisted ≥ 6 months in ≥ 2 settings (e.g., school, home, church). Symptoms have negatively impacted academic, social, and/or occupational functioning. Inpatients aged < 17 years, ≥ 6 symptoms are necessary; in those aged ≥ 17 years, ≥ 5 symptoms are necessary.
Clearly these aren't saying "have they ever misplaced anything?" or "have they ever forgotten anything?". Sure, most people have had some of these things happen some of the time. Yeah, all kids find homework boring, but most kids are still able to do it. Most kids forget things, but aren't losing multiple coats every winter. Most people aren't experiencing these symptoms to such a degree that it significantly impacts their ability to function.
Most people aren't experiencing these symptoms to such a degree that it significantly impacts their ability to function.
it only has to negatively impact academic, social or occupational functioning - according to the patient or parent. ie its subjective, anyone can claim to be having a bad time and that "hey i forget things, im a clutz!" now i have adhd.
i'm confused as to why you think you're suddenly the arbiter of the lived experience of others? all of the questions you're asking are things that are easily found online, but something makes me think you're not after knowledge.
Are you really here trying to claim that ADHD is not a real developmental disorder? To a bunch of people who have lived all their lives with ADHD?
Yes, the symptoms of ADHD are mostly things that most people experience sometimes in their lives. The reason it's a disorder is because they occur commonly enough to affect our lives.
This is not that dissimilar from many other neurodivergencies and mental health issues: Many people feel anxious from time to time. Many people enjoy the rush of gambling from time to time. Most people do not have clinical anxiety or gambling addiction.
Next time you're tempted to come into a thread of people talking about a widely-recognized developmental disorder or mental health problem and drop your superior wisdom that actually, it's not real, and you're much more rational and intelligent than we all are, because you can recognize that the diagnostic criteria are "subjective," which is the same as saying they're meaningless, please consider turning off your computer and going outside instead.
And with ADHD youre saying im more clumsy than normal, but we cannot define normal and we cannot even define abnormal - its completely upto the patient to say if they think its abnormal - unless its a kid then its normally the parent making the claim
Given that tens of millions people have been treated for bipolar disorder with Lithium Carbonate, shouldn't researchers have already seen a correlation with Alzheimer's in patients?
Lithium carbonate was tested and didn't help the mice at all because it was just absorbed by the plaques. The exciting thing is they found a form of lithium (already commonly available as a supplement) which is not absorbed by the plaques and showed a reversal of symptoms with P=0.00007. That's the kind of statistical significance I like to see in my medical papers.
> Replacement therapy with lithium orotate, which is a Li salt with reduced amyloid binding, prevents pathological changes and memory loss in AD mouse models and ageing wild-type mice.
> LiOr is proposed to cross the blood–brain barrier and enter cells more readily than Li2CO3, which will theoretically allow for reduced dosage requirements and ameliorated toxicity concerns.
The important part is this: “a Li salt with reduced amyloid binding”
If cells in the brain are being deprived of lithium due to sequestration by amyloid beta plaques, then a bioavailable form of lithium that is resistant to sequestration may treat the pathology.
> We reasoned that the electrostatic interaction of the Li ion with Aβ deposits would be a function of the ionization capacity of the salt, and that Li salts with reduced ionization might show reduced amyloid sequestration. To assess ionization directly, we measured the conductivity of 16 lithium salts. Inorganic Li salts, including the clinical standard lithium carbonate (Li2CO3, hereafter LiC), showed significantly elevated conductivity, indicative of increased ionization, relative to organic Li salts (P = 8 × 10−4; Fig. 5a and Extended Data Fig. 7a). Of the organic Li salts, lithium orotate (C5H3LiN2O4, hereafter LiO) showed the lowest conductance across a broad Li concentration range (Fig. 5a and Extended Data Fig. 7a) and was therefore selected for further comparison with the clinical standard LiC.
From my not-exactly-expert understanding: lithium is a teeny tiny cation, and it can form compounds on a whole spectrum from ionic to covalent-ish. The authors are observing that lithium orotate does not fully dissociate in water.
For the past 9 years, Android has allowed users to disable location permission per app. More recently, you can choose to share "noisy" location, which just provides an approximation of your location.
Directly from Entrust: "Yes, there has been ongoing internal discussion and reflection on the issues found in this and other incidents, which has led to the action items described previously and ongoing changes, including the decision to revoke the certificates affected by this bug. Exceptional circumstances would need to be provided and justified by the Subscribers. Given the nature of the feedback we have received to date, we doubt that the community has any real interest in anything that Entrust could suggest, except to use against Entrust in a destructive, not constructive, way. We therefore would like more explicit and clear guidelines or a definition of “exceptional circumstances” to be adopted and applied equally to all CAs, perhaps through updates in the CA/B Forum requirements."
A honest translation from the corporate speak would be
We’ve been endlessly talking about our repeated screw-ups, which led us to revoke the affected certificates. If subscribers want an exception, they need to come up with an extraordinary excuse. We don't care, so we demand clear and strict rules about what counts as “exceptional circumstances” that apply to all CAs, and these should be updated in the CA/B Forum requirements. We are big, who are you?
