Could it be that the EVs they were planning were just out of touch with what the market wants? Their zero vehicles look butt-ugly in my opinion. They look like concept cars that are great for show, but no serious buyer would consider them for a daily driver.
I bought the AirPods Max 1 but had to return them because they felt like a vice and were too heavy. I ended up going with the Sony wh-1000xm5, which are much lighter. My only complaint on the Sony is the earcups are not deep enough for my big ears.
It's amusing to me how personal all this stuff is.
The XM5s were super uncomfortable to me (to the point I was relieved when they got stolen) and I ended up going back to Bose even though I liked the sound quality on the Sonys better.
Same experience. Everyone raved about the Sonys and so when my Bose died, I tried them out. I can't stand them! They're way less comfortable and have worse noise cancellation. The lack of buttons drives me crazy. And worst of all - when on flights, the noise cancellation will randomly stop working. Despite flights being one of the main reasons I purchase noise cancelling headphones.
I have the same issue with the shape of my ears not fitting any ANC headphones (and many larger over-ear ones). The only alternative to the APM I found that doesn't hurt after a few hours was the Sonos Ace. Which also have a price that hurts but at least they haven't broken yet while my APM kept breaking (and they're one of the few products where you can't infinitely renew Apple Care).
I watched a news piece about this and alot of people are calling for more testing before sending a crew up. Every mission has risks but there seems to be real concern about the vehicle's re-entry into Earth's atmosphere. Blessings and good luck to the whole team.
Just be aware of dorking around with exposed hardware connected to your $2K MBP. If you end up shorting out your DIY circuit, or have external power supplies connected to your dev board, it's very possible you can fry your laptop.
Best practice is to have a completely opto-isolated USB connection between your dev system and test hardware. You can buy a USB opto-isolated system for like $100 that will tell you downstream currents and isolate your hardware.
I brought a $14k oscilloscope through TSA once. They flagged the unit and proceeded to inspect it, lifting it by the edges of the plastic front cover and trying to remove it while held in mid-air. I kind of freaked out and said "stop" because the oscilloscope was about to take a free-fall. They were not happy that I spoke up, but luckily it averted a crisis.
Wow, I had no idea there is a 15X increase for endurance athletes. Make me want to dial down the running a bit, which make you wonder where the sweet spot is for distance training.
It's rare but can happen where long distance running causes ischemic colitis which is where on a long run enough blood is diverted from the large intestine that it damages the intestine long term. It isn't surprising to me that there's higher likelihood of colon cancer given this. It seems like repeated bouts of lower blood for the intestine on long runs has a cumulative impact and damages the colon even if it doesn't cause ischemic colitis.
This theory has been put forward, but it's important to point out that there is no real evidence yet. An alternative theory is diet, which is also the leading theory for increasing incidences in non-athletes. Highly processed, calorie dense foods have been on the watchlist for a while, and ultra endurance athletes have a special need for these to satisfy their caloric requirements. It could also be a combination of these factors or something else that was missed entirely so far.
I wonder if it's due to diet. Endurance athletes love their simple carbs, highly processed gels. I've seen plenty of cyclists taking gummy bears on rides for fuel, or a concoction that is effectively sugar water to drink
The study referenced is really light on details and they don't say if they controlled for that
Interesting, I wasn't aware of that connection either. I was diagnosed with stage IV colon cancer, but was identified as 'genetic' and not caused by diet or lifestyle. I used to be a heavy runner too, done a few marathons, and plenty more 10k, 8ks etc. Wonder if that could be a correlation... Treatments have it contained/in maintenance so at least I have that going for me.
Ah, that definitely wasn't offered to me as an option. Glad to see the progress however. It would be nice if there was an alternative test so that I could tell my kids it's not genetic.
I have an ultra-runner friend who just got diagnosed with stage 4 colon cancer. Absolutely devastating. He had a colonoscopy just a few years ago. His only symptom was not feeling well after a long race.
It may be the damage of repetitive motion, it may be chemicals released into the bloodstream from endurance athletics. It may be something else. Without knowing the root cause, it's impossible to figure out the "sweet spot"
Could be a lot of things. Lots of long distance runners consume a lot of sugary gels to keep going. Not sure what the typical composition is, but likely lots of glucose and no fibre.
The marathon runners I know also seem to eat tons of junk food, they can get away with it from a weight perspective because a long run will burn it off, but it could have other consequences.
Point being: there's a lot about long distance runners that's quite different from other people.
But the rates of obese people who presumably consume a lot of sugars and carbs are 1/10th the rate of ultra marathon runners. It's scary to think that such conditioned athletes could be subject to this horrible disease.
i saw something recently that pointed to the fact that ultra runners end up with less blood in their guts while running for SO long its leading to cancers and such.
>2x ultra-marathons >26 miles, or at least 5 marathons completed
Yes, and it seems like it's really a 7.5x risk increase. Still pretty spectacular, though!
I really wonder what could cause that. Randomly throwing out possible causes: 1) blood redirected away from gut, 2) overuse of NSAIDS, 3) ultraprocessed foods (gels etc), 4) strange microbiome issues (gels + stress in gut from extreme exertion = altered gut flora?)
The study that found the result is DOI: 10.1200/JCO.2025.43.16_suppl.3619
Which is way more than what original hunters and gatherers ever clock. They do move a lot, but not so much, and they alternate their activities a lot too (running, walking, resting, taking entire days off and just guarding their village).
We're not really optimized for this sort of extreme endurance and long-term development of serious pathologies is unsuprising.
You shouldn't so offhandedly assume a hunter-gatherer lifestyle couldn't lead to issues like increased risk of CRC, or that activities which lead to increased risk of CRC couldn't be what hunter-gatherers did. Evolution is neither fast nor perfectly precise. Plenty of animal populations have common health problems that simply weren't harmful enough to reproduction to be selected out, much less something rare and late-onset like CRC.
I don't assume anything. From what we know about health of the last surviving hunter-gatherers, they suffer significantly less from "diseases of civilization" when taken in proportion to their settled neighbours. Some of those diseases (such as high blood pressure or diabetes 2nd type) seem to be totally absent in them. Cancers do happen, but not as often.
This pattern is quite old. Already ancient Egyptians suffered from civilizational diseases much more than hunter-gatherers, especially the richer ones (heart attacks, gout, cancer).
I won't bother checking or disputing the accuracy of your factual claims, because it does not matter.
Colorectal cancer is not the same thing as high blood pressure, or type 2 diabetes, or any other cancer that isn't colorectal cancer. Diseases are not a monolith and you cannot assume low risk of some diseases means low risk of others. That is wild guesswork passed off as logic, like measuring the shadow your testicles cast on the wall and announcing it is 24.1 degrees Celsius. Ultra-marathon runners also have low risk of type 2 diabetes!
Do you have specific evidence that modern hunter-gatherers have low rates of colorectal cancer that cannot be explained by survivorship bias, screening, genetic differences, and all other confounders, and that they are representative of historical hunter-gatherers? No? Then you cannot confidently conclude that hunter-gatherers didn't experience elevated rates of CRC.
Absolutely, we may have a depressed rate of CRC where ultramarathoners just get back up to the historical baseline. Who knows, but we don’t know it isn’t that.
"Diseases are not a monolith and you cannot assume low risk of some diseases means low risk of others. That is wild guesswork passed off as logic..."
Diseases are not a monolith, but they do tend to arise and fall in some specific clusters, and that is not "logic", good or bad (too many computer-minded people drag logic into the chaos that is biology), but rather a long-time empirical observation, albeit with some exceptions.
You are really obsessed with my testicles. That is a weird comparison, but at least you know that you're not a bot. This would be too weird for a LLM to produce.
In general, I don't think your irony is as strong as you think. Shrinkage of various materials in the cold is the original basis for a thermometer.
Of course it is better to use something better-observable like mercury. But in absence of an industrial civilization, you don't have mercury to measure.
Sigh. Sure, if you had a gun to your head and you knew nothing else, it would be better to guess that a given population (hunter-gatherers) with low rates of some illnesses (T2D, HBP) also had low rates of another illness (CRC) than the reverse. Okay. That's a slightly better-than-chance guess, not anywhere near a solid basis for speculation.
"Anyways, it makes sense that marathoners get CRC because hunter-gatherers probably don't run that much" is bongcloud lalaland tier guesswork.
"makes sense that marathoners get CRC because hunter-gatherers probably don't run that much"
That is a misinterpretation of what I wrote. Let me reformulate.
"Marathons are so much more extreme than what we used to do in the Stone Age, that some pathologies resulting from such long-term physical overload are to be expected." I don't see anything lala about that. You do extreme things, you reap some consequences, sooner or later.
I would say that marathons go beyond our design parameters, but my experience in HN is that the "design" metaphor always conjures some people who consider it a dog-whistle for intelligent design (as opposed to evolution), not just an imprecise metaphor, as metaphors usually are. So I avoid it in order not to attract a senseless fight.
thx! good point. i once heard the cto of supabase say that they didn't hit pmf until they added the copy "open-source firebase alternative" to their website copy & overall product positioning. that was when it finally clicked for devs.
that said, if we're so fortunate to get enough users for this become a problem, i won't hesitate to take it off :)
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