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While uncommon, Aspirin can cause Reye syndrome in children, which can lead to death or cause permanent disability.

Paracetamol does not cause such harmful effects if used as directed. It definitely should be used as a first-line treatment (if needed) in case of fever or pain.

Edit: typo


> Aspirin can cause Reye syndrome in children

This has never been demonstrated


GDPR is not a directive, but a "regulation" (hence the name, General Data Protection Regulation). It is enforceable "as is" in the whole EU without the need to be transposed into the various national laws.


> and there are reasons why they're not part of any drugs

Caplacizumab (Cablivi®) is a Nanobody (2 VH units linked together) approved by the EMA since 2018 (and by the FDA since 2019).


Mind you this is used for TTP and thrombosis, where short lifetime is a benefit. You want to remove the clotting factor now, not forever. (We have drugs for that too.)


Short lifetime can be a benefit for anti-Covid medication too. An antibody could cross react with a vaccine and hamper the immune system response, preventing it from launching a proper reaction and creating proper immunity. You don't want the person having to wait for weeks while being vulnerable until they can get a vaccine after a successful therapy with antibodies.

But of course, distribution is a headache.


A person having an an immune system that can be vaccinated with traditional vaccines (including mRNA), while not developing meaningful resistance (such that a second infection isn't serious even if possible) from an infection where they needed antibodies, doesn't seem very likely. And if they were treated with antibodies once, they could probably just use them again, so it doesn't seem important.

Nevertheless, it would still be moderately impractical in the sense that a vaccination immunity should (probably?¹) be more effective than immunity after an infection, but it may not properly develop until the vaccine is administered without (much) antibodies present.

¹ is there any evidence or a sound supported theory that a coronavirus vaccine is more effective and/or long lasting than immunity after an infection?


Touche, there do seem to be approvals. I'll edit my post.


One example of a very new drug; do you have any others? Any studies on its efficacy and side effects?


It’s a bit unfair to ask the parent to do this legwork. The fact that it got approved implies that it is effective and that side effects are rare and/or relatively minor.

Edit:

From the phase II trial:

“ Adverse events overall were similar between groups, with the exception of bleeding, which occurred more often with the immunoglobulin treatment (54% versus 38%). The two participants who died were both in the placebo group.” https://www.medpagetoday.com/Cardiology/VenousThrombosis/561...


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