There are several ways that dark matter might exhibit detectable interactions. For example, it could undergo weak interactions with itself or with ordinary matter. (See WIMPs.) It could also undergo some antimatter-annihilation interaction, emitting e.g. a Z boson, which could decay to a detectable particle-antiparticle pair. We might be able to observe Z bosons from matter interactions decaying to dark matter pairs, which would manifest as an unexplained shortage of matter after a collision. We're still looking for any such interactions.