I've been using macports for ages, nothing wrong with it. Okay, it does not check to see the stock installs of OSX, and installs its own ruby, perl, python etc. Apart from that it's been very reliable.

My main problem with macports has been that it occasionally does not play nicely with manual source-installs, or any other package manager. And damn near everything needs sudo.

Everything I've needed has been available in homebrew, and more up-to-date and better isolated and hasn't collided with anything yet. I haven't used it as long as I've used macports, but so far it has been a far more pleasant experience. And incomparably faster - I swear, macports has a sleep() call in every operation. Very much recommended if you haven't tried it, and it cleans up nicely too - you just delete its single folder.