Not quite first class citizen, but you might like sqlx. At least it embraces the idea that writing SQL directly is in fact a good idea and helps you to do so safely.
LINQ? Just throwing it out there; obviously not everybody can or wants to run a C#/.NET stack, but entity framework (core) is about as close as you can get to the perl and regex integration. I think Ruby on Rails gets there too, but I'm not a RoR guy, so I can't comment.
The devil is of course in the details, but it's a nice dream.